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SERENE (Tube 8)

Relaxation & Sleep Aid Supplement (8 Capsules)

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Natural Sleep Medication

SERENE is a natural sleep supplement to effectively support relaxation and calming to the body and mind and to promote healthier sleep. It has highly concentrated extracts of the most powerful organic relaxants and soporifics in a precisely-crafted balance.

This OTC natural sleep aid, relaxation and anti-stress support supplement is non-addictive, safe, has no side-effects or next-day hangover, and is an excellent nutritional solution for occasional sleeplessness, muscle soreness, or just to unwind and relax.

How does SERENE relaxation and sleeping support work:

SERENE can be used in half dose to promote a relaxation response, soothing muscles and tension, as well as helping the body relieve stress.

SERENE in full dose causes drowsiness and promotes a deep, healthy, restful sleep. It works fast, in 30-60 minutes, gently helping you sleep all through the night, to wake up refreshed and without feeling groggy.

SERENE is non-narcotic! Studies show that the ingredients in SERENE safely and effectively promote healthy sleep with no risk of dose escalation or tolerance buildup, no negative side-effects or withdrawal issues, and no next-day hangover or grogginess. It can help you naturally get the deeper sleep you need so you wake with energy, vitality, and renewed vigor for life.

SERENE, a completely natural, vegetarian supplement, is non-addictive, and can be safely taken for extended time without ill effect, unlike some prescription sleep medications and drugs. It is also completely free of fillers, dyes, soy or gluten.

Click the ingredients tab for complete details.

Wash away the day with SERENE!

how to get better sleep

Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving: 1600mg
Ingredient Amount Daily Value
Calcium (carbonate/citrate) 100mg 25%
Magnesium (oxide/glycinate) 100mg 100%
Proprietary Mix:  1600mg  
SunTheanine (L-Theanine)   *
Rafuma Leaf Extract   *
Ashwaganda (1.4% withanolides)   *
Humulus Lupulus   *
L-Tryptophan   *
Jujube   *
Chamomile   *
Inositol   *
Beta-phenyl-gamma-aminobutyric acid (GABA)   *
Lemon Balm   *
Valerian Root (1% valernic acids)   *
* Daily value not established    
 Other Ingredients:Magnesium Stearate, Stearic Acid,
 Microcrystalline Cellulose, croscarmellose sodium, and silicon dioxide

SERENE Muscle Relaxation, Sleep Aid Ingredients

SERENE natural muscle relaxant and sleep support supplement contains ingredients that have shown in scientific research to have positive effects on muscular relaxation, mental calmness, and sleep quality. We use premium grade extracts in a scientifically-crafted balance to effectively help support the relaxing of your body and mind, to help bring on sleep faster, ensure a deeper, more restful quality sleep, and allow you to wake refreshed and without any hangover.

The advanced formula consists of:

L-TheanineL-Theanine is an amino acid that is one of the main components of green tea. Research has shown that L-Theanine can significantly increase levels of GABA, a key brain chemical known for its calming effects, and dopamine, which effects mood.

L-Theanine readily crosses the blood-brain barrier of humans and exerts subtle changes in biochemistry. An increase in alpha waves has been documented (Relaxation and immunity enhancement effects of gamma-aminobutyric acid administration in humans. Abdou AM, Higashiguchi S, Horie K, Kim M, Hatta H, Yokogoshi H), and the effect has been compared to getting a massage or taking a hot bath. Research with human volunteers has demonstrated that L-Theanine creates its relaxing effect in approximately 30 to 40 minutes after ingestion. L-Theanine directly stimulates production of alpha brain waves, which creates a deep state of relaxation while maintaining mental alertness.


L-Tryptophan is a basic, essential amino acid (cannot be synthesized by the body and must be absorbed through diet) that is used in the formation of 5-htp, serotonin, and melatonin, which amongst other things, help tell your body to relax and sleep, modifying mood and stress responses, and sleep cycles (Hartmann E (1982). "Effects of L-tryptophan on sleepiness and on sleep". Journal of Psychiatric Research 17.)


Beta-phenyl-gamma-aminobutyric acid
 is a derivative of the the brains main calming neuro-transmitter GABA that successfully crosses the blood-brain barrier, unlike GABA itself. Clinically, it has indicated supportive effects for anti-anxiety and muscle relaxation (Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks - Yoto A, Murao S, Motoki M, Yokoyama Y, Horie N, Takeshima K, Masuda K, Kim M, Yokogoshi H.)

(Awad R, Levac D, Cybulska P, Merali Z, Trudeau VL, Arnason JT. Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system. Can J Physiol Pharmacol. 2007 Sep;85(9):933-42. )

ValerianValerian has been used as a sleeping aid for hundreds of years. It is well known for its sedative qualities (through GABA release), its ability to relax the central nervous system, to calm smooth muscle (due to the valepotriates and the isovaleric acid,) and to improve sleep latency (ref: A systematic review of insomnia and complementary medicine. Sarris J, Byrne GJ.) At least two double-blind studies have demonstrated that valerian root extract can significantly reduce the amount of time it takes people to fall asleep without changing the normal stages of sleep.


JujubeWild Jujube seed has been highly regarded by the Chinese for centuries for its supportive relaxation properties and extremely low toxicity. It is used throughout Asia as the most popular sedative and calming agent. A number of compounds are present in jujube, including saponins, jujubosides and triterpenoic acids, but it appears that the saponins (and flavonoids) are the main active ingredients in terms of sedation and relaxation. Studies at the College of Food, South China University of Technology, investigated the sedative effects of the compounds extracted from jujube herb and orally administered to mice separately. Results show that flavonoids and saponins significantly prolonged time spent in deep sleep.


Phosphatidylserine, an antioxidant, has been shown to enhance brain function and memory, decrease anxiety and depression, improve mood and sleep quality, and enhance metabolism.




Inositol is a form of sugar found in citrus fruit, bananas, nuts and seeds, and various foods.. It has been classified as a member of the vitamin B complex, and is often referred to as B8 (it is technically not a vitamin.) Studies have shown that inositol can increase serotonin levels in the brain, influencing relaxation and sleep.


Magnolia Bark
Magnolia Bark has been shown in numerous studies to support regulation and calming of the central-nervous-system. Along with magnolol, magnolia bark contains another active chemical called honokiol. According to researchers at Nanjing University in China (published in Nov. 28 issue of Progress in Neuro-psychopharmacology and Biological Psychiatry,) the extracts from magnolia bark have significant antidepressant properties, as they help regulate brain chemicals that are associated with depression.

Lemon Balm

Lemon Balm (or Melissa) is a member of the mint family and has been used for centuries to help with mood and sleep. In one study of healthy volunteers, a daily dose of 600 mgs of lemon balm for a week improved mood, and boosted both calmness and alertness. Several studies show that lemon balm, in conjunction with other herbs such as valerian, hops and chamomile, enhances sleep (Kennedy DO, Little W, Haskell CF, Scholey AB. Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress. Phytother Res. 2006;20(2):96-102.).

Both Germany’s Commission E (equivalent to FDA) and the British Herbal Pharmacopoeia approve the use of lemon balm for sedative purposes. It was recently touted by Dr Oz for its ability to help you sleep better.

Humulus Lupulus
Humulus Lupulus
, or hops, is well known for its sedative properties. The resin of hops (methylbutenol) increases the activity of the neurotransmitter GABA, inhibiting the central nervous system. Several studies have shown that the combination of hops and valerian are effective for inducing sleep. (Eur J Med Res. 2008 May 26;13(5):200-4.)

Again, Germany’s Commission E and the British Herbal Pharmacopoeia approve the use of hops for sedative purposes.

, from the Withania somnifera plant, is a member of the nightshade family and has long been prized for its ability to help the body deal with stress as an adaptogen (known as the 'Queen' of ayurvedic.) It has an anxiolytic effect in social anxiety tests and appears to significantly reduce the symptoms of stress and its co-morbidities (fatigue, temporary cognitive impairment, etc.)


provides a strong analgesic effect, reducing tension and soothing muscle cramps and aches. Passionflower actually binds to benzodiazepine receptors in the brain which reduces anxiety thus helping you sleep. In fact, a noted sleep expert says that not only does passionflower induce deeper, more natural sleep, but it also helps improve concentration when you're awake.



has the same action as passionflower by binding to benzodiazepine receptors. One Japanese study of rats found that chamomile extract helped the rats fall asleep just as quickly as rats that were given actual benzodiazepine (a tranquilizing medication.)


Calcium & magnesium
Calcium and Magnesium deficiencies may produce muscle spasms and cramps, anxiety, nervousness, irritability, lack of sleep or restless sleep and physical fatigue. Supplementing these ingredients has positive effect on sleep patterns.(Study on selected trace elements and heavy metals in some popular medicinal plants from Sudan. Ebrahim AM, Eltayeb MH, Khalid H, Mohamed H, Abdalla W, Grill P, Michalke B.)


Relaxation & Sleep Support Usage

To Provide Relaxation & Tension Relief to Muscles - Take 2 capsules on an empty stomach to relax and soothe aching muscles, or to help reduce muscle pain, or simply to relax and soothe your mind.

To Support Healthy, Deep & Restful Sleep - Take 4 capsules 60 mins before bedtime on an empty stomach and experience deeper and more restful sleep. 

Relaxation & Sleep Aid Support Warnings

Do not use if you are pregnant, may become pregnant, or breastfeeding, are elderly, or under the age of 18. Do not drive, use machinery, or do any activity that requires alertness. Do not take if currently taking any prescription medication or you are receiving medical treatment without consulting your physician. Discontinue immediately if any adverse effects occur and contact your health care practitioner. KEEP OUT OF REACH OF CHILDREN.

Sleep Supplement Reviews / Testimonials

The testimonials below are taken from our customer feedback pages across the internet and do not represent claims regarding the effectiveness of SERENE to diagnose, treat, cure or prevent any disease.

"Deep, calm sleep, very relaxing ..."

SERENE works beautifully, takes about 1/2 hour or so. Deep, calm sleep, very relaxing.

Margot - Mesa, AZ


"didn't know what had hit me ..."

I have trouble getting my mind to stop racing in order to get a good night's sleep or waking and not being able to get back to sleep. I wanted to go the natural route so took a chance and purchased this sleep aid.

I took the recommended dosage and went to bed thinking here was going to be another product that wouldn't deliver. Was I wrong! Within 20 minutes I didn't know what had hit me as I was sound asleep- and in a deep, restful sleep as well. I didn't experience any grogginess in the morning! I now have hope when I know it's going to be one of "those nights".

I will be purchasing more and would recommend this product although I would adjust to a lesser dose depending on your body size. I'm rather petite and will probably get adequate results.

Sue F. - Denver, CO


"I can't believe it's an over the counter supplement."

SERENE is so effective for me I can't believe it's an over the counter supplement. I had a real tough time getting off Ambien and it really messed with my head. I was really worried I wouldn't be able to find help for my insomnia once I had stopped the drugs, and for a while I tried a slot of sleep aids, from nyquil to unisom and everything in between. Most just did not work for me and the ones that did made me feel fogged out and crappy the next day. So I tried your free samples and I have to say I was delighted, for sure. They didn't seem to make me drowsy at first, but all I know was shortly after I fell asleep without the normal tossing around fiasco and woke up 7 hours later feeling great! I tried it again the next night to see if it was a fluke. Same thing. I love how I just dropped right off and slept right through. It's really weird but I keep thinking at first it's not making me sleepy, but then it works. It is hands down the best natural sleeping supplement I have ever used. I bought a bottle the next day and I have been taking it for 2 months now. I wanted to say thank you so much. Excellent sleep product.

Cherry L. - Henderson, NV


"Helps me relax and really helps me sleep ..."

Wow what a strong relaxant SERENE is. I was not expecting it to be so good. Helps me relax and really helps me sleep, which I needed. Thanks.

Ted R. - Tampa, FL


"... a good night sleep without the morning after hangover"

After trying everything imaginable OTC to ease my lower back pain and let me fall asleep at night, SERENE has done the trick for me. I get a good night sleep without the morning after hangover that so many other products seem to give you. Thanks a lot for offering this product.

Melinda W. - Livonia, MI


"works great as a sleep aid ..."

Good product, SERENE. I love the gentle, smooth relaxed feeling and it works great as a sleep aid, though I take 5-6 capsules for that.

Tammy W. - Houston, TX


"I don't wake up feeling like I'm moving thru mud ..."

I have trouble staying asleep all night. When I use SERENE I don't have that problem and I don't wake up feeling like I'm moving thru mud, like an over the counter product. Excellent product. Thank you.

Cheri K. - Oceanside, CA


"really works for me..."

SERENE really works for me. It has helped me sleep well all through the night. I have tried all the non prescription sleeping pills, and this one is the best I found.

Julie G. - Winton, AU


"slept right through and felt great the next day."

At first I didn't think it did much for me, I took 2 capsules and felt nothing significant. I suppose I felt a bit relaxed, but I know supplements can have varying effects depending on many factors, so I tried it again that evening (I have a lot of trouble sleeping and don't like sleeping pills) and took the full dose and boy was I glad. I actually drifted off without all the drama, no tossing and turning like I always do, no waking up, I just slept right through and felt great the next day. And that's saying something because I'm always tired in the am. I decided to write this review to let you know that over the last week, I have taken Serene a few times and it is really good. Some days after work I take it for a chill effect, but it really does help me sleep better. Quality stuff, so thanks a bunch. You have a loyal customer.

Tommy S. - Las Vegas, NV


"top notch product..."

I really can't say enough about how effective SERENE has been for me. I know this is a natural OTC product but it works so well at relaxing me and helping me sleep better. I have had a lot of problems and I finally found a solution. Thanks for the top notch product.

Mack G. - Hull, UK


"very conducive to relaxation ..."

SERENE is very good. It is very conducive to relaxation. I don't want to run out. I have told my friends about it too.

Bettye D. - Cabot, AR


"stronger than stated ..."

SERENE is truly effective. It is actually stronger than the recommended dose for me. I took 2 and it knocked me out after really relaxing me at first. Very good product, I will recommend it.

Gary D.. - Arcadia, CA


"has helped me so much to sleep ..."

Thank you! We are in a flooded area in Colorado and SERENE has helped me so much to sleep through all the devastation.

Pennie H. - Lyons, CO


"super supplement that does it's job."

Wanted to drop a quick line to say how good SERENE is. I tried the samples first and I thought that was great that you offer them. I still wasn't expecting much though. The first night I took the pills I slept better than I have in years. I felt great the next day, no drowsiness or fogginess like other products left me. I am so glad I tried it and I have just ordered several bottles and have told some of my friends how it helped. Thanks for offering a free try and for such a super supplement that does it's job.

Jackie J. - S. Ranch, CA


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